GS-441524: the FIP antiviral
GS-441524 is the most studied and widely used nucleoside antiviral for FIP treatment, with cure rates above 85% in multiple clinical studies.
How does GS-441524 work?
GS-441524 is a nucleoside analogue that inhibits the RNA-dependent RNA polymerase of the FIP virus. Simply put: it penetrates infected cells and prevents the virus from replicating. Without viral replication, the cat's immune system can recover and eliminate residual virus.
Recommended dosing
| FIP Form | Dose | Route | Duration |
|---|---|---|---|
| Standard wet/dry FIP | 4-6 mg/kg/day | SC or oral | 84 days |
| Dry FIP without neuro/ocular | 6 mg/kg/day | SC or oral | 84 days |
| Neurological or ocular FIP | 8 mg/kg/day | SC preferred | 84+ days |
FAQ
Questions about GS-441524
Clear answers to the most common questions.
Standard dose is 4-6 mg/kg/day for wet FIP without neurological or ocular involvement. Neurological or ocular forms require 6-8 mg/kg/day. Always under veterinary supervision.
Yes. There are oral formulations (capsules) that avoid daily subcutaneous injections. Oral bioavailability varies by brand. Some brands offer exclusively oral, others injectable, and some both options.
Standard treatment lasts 84 days (12 weeks). Neurological forms may require extensions of an additional 84 days. After 84 days, there is an observation period of another 84 days before declaring a cure.
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